Synaptic Pruning in the Developing Nervous System - Using light and serial electron microscopy, Jeff Lichtman and colleagues assessed the how axonal branching and synaptic connectivity change with dev...
A Mouse Model for Mitochondrial Deafness - Why do mitochondrial diseases often affect very specific tissues, such as cells in the inner ear? Gerald Shadel's mouse model reveals how mitochondrial stres...
Evaluating the Utility of PDE10 Inhibition in Huntington’s Disease
Beaumont et al. demonstrate that acute PDE10 inhibition boosts diminished corticostriatal input and indirect pathway output in symptomatic HD models, despite loss of PDE10. Their data provide rational...
Octopamine Regulation of Sleep - An understanding of sleep requires identification of the circuits that mediate the action of specific sleep:wake-regulating molecules. Watch and listen as Amanda Crock...
How to Undress an mRNP - Nonsense-mediated mRNA decay requires the RNA helicase Upf1, but as Jens Lykke-Andersen and colleagues explain, Upf1 does more than unwind RNA. It also strips off the mRNA's p...
Evolving Roles for Inhibitory Interneurons in Seizures
Evolving Roles for Inhibitory Interneurons in Seizures. Using a combination of optogenetics and calcium imaging, Khoshkhoo et al. show how various classes of interneurons play distinct and evolving ro...
Neuronal Microcircuits Underlying Spatial Cognition - The functional microcircuits underlying spatial representations in medial entorhinal cortex (MEC) have not been described. Through their discovery...
A Novel Analgesic Isolated from a Traditional Chinese Medicine
Research conducted through a collaboration between scientists at the University of California, Irvine (UCI) and the Chinese Academy of Sciences (CAS) has identified a compound within the plant Corydal...
