Gene Discovery in Mendelian Brain Disorders - A Center for Mendelian Genomics gene discovery study is presented that utilizes genomic approaches, which detect rare variant—single nucleotide variants (...
Not miRly a Knockout - Drs. Wang and Olson discuss their work on miR-129, as well as the general idea that gene loci encoding both a protein and an intronic microRNA commonly share regulated expressio...
Portabella: A New Player in Neurotransmission - David Krantz and colleagues report the discovery of portabella, a Drosophila gene that is structurally similar to known vesicular transporters and is ex...
Depolarized Subicular Microcircuits in Epilepsy. The subiculum is crucially involved in spreading and generalizing hippocampal seizures. Wang et al. demonstrated depolarized GABAergic signaling caused...
Developmental milestones punctuate gene expression in the Caenorhabditis embryo. A fundamental question in developmental biology relates to the connection between morphological stages and their underl...
Connecting Parkinson's Disease Gene Functions - This video describes the identification of functional interactions between Parkinson's disease genes VPS35, EIF4G1, and alpha-synuclein. Aaron Gitler an...
Memory Enhancement by Targeting NR2B Cell Surface Regulation
Many neurological disorders, such as Alzheimer's disease, are characterized by learning and memory deficits, for which cognitive enhancement is considered a valid treatment strategy. Plattner and coll...
Combinatorial Genetic Targeting of GABAergic Neurons
Combinatorial Genetic Targeting of GABAergic Neurons - Article: Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex
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Mitochondrial links to genomic instability in aging
Mitochondrial links to genomic instability in aging - Understanding why our genomes become more prone to mutations as we age is a key goal of ageing and cancer research. Dr. Dan Gottschling and his co...
Neuro In Silico/ Cell, Oct. 8, 2015 (Vol. 163, Issue 2) - Henry Markram and colleagues outline the building of a detailed digital reconstruction of a brain region and the features that emerge when the...
Deciphering Gene Expression Patterns - Nir Yakoby and Stas Shvartsman discuss the gene expression profiling project that led them to develop this framework for cataloguing and interpreting gene expres...
A 3D Map of the Human Genome - Suhas Rao and Miriam Huntley (of the Aiden Lab) describe a 3D map of the human genome at kilobase resolution, revealing the principles of chromatin looping. Guest Origam...
Plasmodium Sporozoites Form Transient Vacuoles during Cell Traversal
Plasmodium Sporozoites Form Transient Vacuoles during Cell Traversal - Spinning disk confocal microscopy of HepG2 cells expressing a fluorescent marker of the plasma membrane, N20-mCherry, showing egr...
Patients with schizophrenia show decreased activation of the mediodorsal thalamus but it is unclear whether this could generate cognitive deficits. This study shows that a primary decrease in the acti...
How Do Sex Hormones Control Behavior? - Nirao Shah and his colleagues explain how single genes control specific features of sexually dimorphic behaviors, such as the willingness to mate, speed of coll...
