Human Mutation - Miao-Xin Li and Mulin-Jun Li

Human Mutation - Miao-Xin Li and Mulin-Jun Li - YouTube...

Evaluating the Utility of PDE10 Inhibition in Huntington’s Disease

Beaumont et al. demonstrate that acute PDE10 inhibition boosts diminished corticostriatal input and indirect pathway output in symptomatic HD models, despite loss of PDE10. Their data provide rational...

Details of How Nuclei Are Harvested upon Sucrose Gradient Ultracentrifugation

Details of How Nuclei Are Harvested upon Sucrose Gradient Ultracentrifugation ...

In Vivo Imaging of Neuron and Glial Cell Activity with a New GCaMP5 Reporter Mouse

In this video abstract, we present a new Cre-dependent GCaMP5G reporter mouse (PC::G5-tdT) targeted the PolR2a locus. We demonstrate the utility of this mouse line for imaging calcium activity in neur...

Portabella: A New Player in Neurotransmission

Portabella: A New Player in Neurotransmission - David Krantz and colleagues report the discovery of portabella, a Drosophila gene that is structurally similar to known vesicular transporters and is ex...

Myc and Multiple Myeloma: Drugging the Undruggable

Myc and Multiple Myeloma: Drugging the Undruggable - Reporting a new small-molecule inhibitor of chromatin-binding bromodomains, James Bradner and Constantine Mitsiades offer a back-door route to bloc...

Superresolution for Thicker Samples, Part 1

Superresolution for Thicker Samples, Part 1 ...

Snakes on the DNA Plane

Snakes on the DNA Plane - How can protein complexes slide along DNA while still remaining wrapped up in its strands? Using optical tweezers and a baseball, Taekjip Ha and Ruobo Zhou show us how in thi...

Antimicrobial Discovery Gets Put on Display / Cell Jan. 25, 2018 (Volume 172, Issue 3)

Antimicrobial Discovery Gets Put on Display / Cell Jan. 25, 2018 (Volume 172, Issue 3) - YouTube...

Activating Genius; Lesson 1 Neurogenesis

Orchestrated amplification and differentiation of intermediate progenitors governs the evolutionary expansion of the cerebral cortex. Fang et al. report that Axin serves as a master scaffold that dete...

Why Evolution is True and Why Many People Still Don't Believe It (Jerry Coyne, 2012)

Pardis Sabeti and colleagues describe their analysis of human sequence data from the 1000 Genomes Project to reveal hundreds of potential adaptive variants. In a second study, the authors engineered m...

Deciphering Gene Expression Patterns

Deciphering Gene Expression Patterns - Nir Yakoby and Stas Shvartsman discuss the gene expression profiling project that led them to develop this framework for cataloguing and interpreting gene expres...

Mismatch Receptive Fields in Mouse Visual Cortex

Mismatch Receptive Fields in Mouse Visual Cortex - Zmarz and Keller show that in V1 neurons, sensorimotor mismatch responses, like visual responses, are confined to specific regions of the visual fiel...

Zeroing in on Repetitive Behaviors

Zeroing in on Repetitive Behaviors. Thomas Südhof and colleagues reveal that neuroligin-3 mutations enhance repetitive behaviors similar to those seen in autism spectrum disorders by selectively affec...

YouTube Science Video

This video abstract accompanies the article The resilience of the forest field layer to anthropogenic disturbances depends on site productivity by Kaupo Kohv, Martin Zobel, Jaan Liira, published in Ca...

How to Inflame Cancer Growth / Cell, July 13, 2017 (Vol. 170, Issue 2)

How to Inflame Cancer Growth. Cancer cells are surrounded by normal cells like fibroblasts and immune cells, but can they be corrupted to promote growth of a tumor? In this video abstract, Andy Minn a...

DeCoN: High-Throughput Investigation of the Cortical Transcriptome

DeCoN: High-Throughput Investigation of the Cortical Transcriptome - Decoding the signals that shape and maintain the extraordinary neuronal diversity of the mammalian cortex remains a challenge. In t...

Tomatoes Show Their Good Traits/Cell, May 18, 2017 (Vol. 169, Issue 6)

Tomatoes Show Their Good Traits/Cell, May 18, 2017 (Vol. 169, Issue 6) ...

Why Scratching an Itch Makes You Itch More

Why Scratching an Itch Makes You Itch More - Dr. Zhou-Feng Chen’s team explains why scratching make you itch more. You scratch an itch to cause minor pain, which prompts the brain to release serotonin...

Intact Mirror Neuron Function in Autism

Intact Mirror Neuron Function in Autism - It has been proposed that dysfunction of the mirror neuron system may underlie the social difficulties associated with autism. Watch and listen as Ilan Dinste...