When Genetic Instability Is a Good Thing - Dr. Orr-Weaver discusses her group's work on regulatory programs that amplify (or suppress) overreplication of cell-type-appropriate genes in the Drosophila ...
Membrane Tension Maintains a United Front - Using his own neutrophils, Orion Weiner demonstrates how physical forces and not diffusible factors ensure that migrating cells have a single leading edge....
Nels Elde describes how poxviruses utilize gene "accordions" to increase the sampling potential for mutations in a small number of genes, revealing a new mode of virus adaptation....
How Does the Tumor Microenvironment Fuel Relapses after Chemotherapy?
How Does the Tumor Microenvironment Fuel Relapses after Chemotherapy? - Mike Hemann and Luke Gilbert explain how a chemoprotective niche in the thymus helps cancer cells hide out during treatment....
Differential Hippo Signaling in Early Mouse Embryos
Differential Hippo Signaling in Early Mouse Embryos - Hiroshi Sasaki discusses his group's recent findings on the role of differential Hippo signaling in regulating cell fate during trophectoderm form...
Th17 Cells in Autoimmune Disease/ Cell -- Single-cell RNA-seq coupled to a new functional annotation approach identifies distinct functional states of Th17 cells and the underlying molecular mechanism...
Li et al. show that thalamocortical neurotransmission is required for the normal columnar, laminar, morphologic, and molecular-genetic development of sensory cortex....
Protons Away for Sperm Activation! - Human sperm are activated to swim more vigorously once they enter the female reproductive tract. Watch and listen as Lishko and Kirichok take you on a brief, pers...
Scar in the Gut/ Cell, Oct. 8, 2015 (Vol. 163, Issue 2)
Scar in the Gut/ Cell, Oct. 8, 2015 (Vol. 163, Issue 2) - Yasmine Belkaid and her colleagues at NIH in their recent Cell paper show that a single episode of acute gut infection will cause an "imm...
Personalized Nutrition/ Cell November 19, 2015 (Vol. 163, Issue 5)
Personalized Nutrition/ Cell November 19, 2015 (Vol. 163, Issue 5) - Doctors and nutrition specialists keep telling us what foods are good and bad for our metabolism and health. But does it work for e...
The Role of RNA Binding Protein hnRNP A2/B1 in ALS
The Role of RNA Binding Protein hnRNP A2/B1 in ALS - What goes wrong during the devastating disease ALS? Gene Yeo, Fernando Martinez, and colleagues from across the country uncover the role of RNA bin...
Visual control of octopus arm movements - Octopuses are known among invertebrates for their sophisticated behavior and the task they face of controlling eight flexible arms is a daunting one. As expla...
Mitochondrial links to genomic instability in aging
Mitochondrial links to genomic instability in aging - Understanding why our genomes become more prone to mutations as we age is a key goal of ageing and cancer research. Dr. Dan Gottschling and his co...
