How Attenuated Viruses Become Virulent / Cell, March 23, 2017 (Vol. 169, Issue 1)
How Attenuated Viruses Become Virulent. In this issue’s Video Abstract, Raul Andino describes the evolutionary strategies by which vaccine strains can become pathogenic, and provides a framework for r...
Oiling the Immune System for Top Performance - Omega-3 fatty acids are a popular diet supplement, but the mechanisms underlying their beneficial properties have been mysterious. Watch and listen as Je...
A Journey Into Entorhinal Cortex | Edvard and May-Britt Moser | NTNU
Kimberly Stroka and colleagues describe a propulsion mechanism for cancer cells that relies on a spatial gradient of channels and pumps in the plasma membrane, rather than acto-mysosin contractility....
Ferroptosis: A New Type of Programmed Cell Death - Distinct from apoptosis, necrosis, and autophagy, "iron-dependent cell death" emerged while Brent Stockwell and his lab were investigating ...
Sensing DNA Damage, ATP Orders an Mre11-Rad50 Clamp Down
Sensing DNA Damage, ATP Orders an Mre11-Rad50 Clamp Down - By trapping Mre11-Rad50 in mulitple states, Karl-Peter Hopfner and colleagues discover that Mre11-Rad50 transiently assembles into an ATP-con...
Sequential and Rhythmic Production of Somites - Illustrated with the developing zebrafish embryo, somitogenesis is a sequential and rhythmic process that subdivides the mesoderm of the vertebrate embr...
Cell Surface Topography Is a Regulator of Molecular Interactions
A neutrophil labeled with Alexa-488-conjugated anti-L-selectin spreads onto and engulfs an IL-8-coated glass bead in bright field, epifluorescence, and TIRFM. See the paper by Lomakina et al. in the S...
TRPA1 Gain of Function Linked to Human Pain - Mutations in ion channels underlie multiple neurological disorders, including pathological pain states. Although previous work with knock-out mice has sug...
Obtaining a clear picture of the proteins that interact with the Huntingtin protein will provide clues for the development of Huntington's disease therapies. In this study, William Yang and colleagues...
Restoring Reality Monitoring in Schizophrenia - Reality monitoring, the ability to distinguish internally generated information from external experiences, is impaired in schizophrenia patients. In an ...
