Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer
Richard Gregory and colleagues reveal that the Hippo-signaling pathway and its downstream target YAP regulate miRNA biogenesis in a cell-density-dependent manner, which may be responsible for the wide...
Bidirectional Transcription and Antisense Repression of ataxin-7
Bidirectional Transcription and Antisense Repression of ataxin-7 - CAG repeat expansions in the ataxin-7 gene cause the neurodegenerative disorder SCA7. Al La Spada and colleagues have discovered tha...
Breaking Bcr-Abl Resistance - Giulio Superti-Furga discovers a new vulnerability of drug-resistant Bcr-Abl mutants—blocking their SH2 domain interface enhances the effectiveness of tyrosine kinase inh...
Thalamic Mechanism of Parkinson Disease. Hyper-inhibition of thalamic neurons by the basal ganglia inputs has been proposed as a mechanism for Parkinson's disease. This study shows that rebound firing...
2012 Three Minute Thesis Runner Up - Billie Ganendran
Billie Ganendran (Physical, Environmental & Mathematical Science, UNSW Canberra), runner-up in the 2012 UNSW Three Minute Thesis competition, gives her presentation - "The curious mix of peng...
Ronald Evans and colleagues show that activation of the vitamin D receptor sensitizes the stroma of pancreatic cancers to conventional chemotherapy, boosting its efficacy and survival rates....
Chivalrous insects - Males of many species guard their mates to prevent them from mating with rival males, and to thusly ensure paternity. Generally this represents a source of conflict between the se...
Phase Transition in Disease/ Cell August 27, 2015 (Vol. 162, Issue 5)
Phase Transition in Disease/ Cell August 27, 2015 (Vol. 162, Issue 5) - In this video and the accompanying Cell paper, the Tony Hyman and Simon Alberti groups at Max Planck Institute propose an intere...
The Bacterial Effector VopL Organizes Actin into Filament-like Structures
Michael Rosen and colleagues find that a pathogen effector protein assembles actin filaments through the collaborative action of an organizing domain that templates filament structure through both low...
Andy Dillin and colleagues show that, in the nematode worm C. elegans, activation of the unfolded protein response (UPR) regulator XBP-1 in neurons produces a signal that stimulates UPR in intestinal ...
