Molecular Structure of β-Amyloid Fibrils in Alzheimer's Disease Brain Tissue
Robert Tycko and colleagues find that amyloid fibrils derived from AD patient brain tissue reveal a single predominant structure within a patient sample but with key differences between samples, raisi...
Sortilin Link to Dementia Pathophysiology - Mutation of the gene for PGRN causes Fronto-Temporal Lobar Degeneration but the mechanistic link between reduced PRGN levels and neurodegeneration is unknow...
D2 Receptor-DISC1 Complex and Antipsychotic Effects
D2 Receptor-DISC1 Complex and Antipsychotic Effects. Our lab has identified a novel interaction between D2 receptor and DISC1, and this complex was found to be increased in postmortem brain tissues o...
A Window into the Immune Landscape of Lung Cancer/Cell, May 4, 2017 (Vol. 169, Issue 4)
A Window into the Immune Landscape of Lung Cancer/Cell, (Vol. 169, Issue 4). mmunotherapy is revolutionizing treatment of patients with advanced cancer. But could it help patients with early stage tum...
Kinesin-1-Mediated Transport of AMPARs Contributes to Synaptic Strength
In this video, Hoerndli et al. describe in vivo studies of AMPARs transport in defined neurons. They propose a model in which the delivery, removal and redistribution of AMPARs by the kinesin-1 microt...
Why Scratching an Itch Makes You Itch More - Dr. Zhou-Feng Chen’s team explains why scratching make you itch more. You scratch an itch to cause minor pain, which prompts the brain to release serotonin...
Remote Control of pmCRY2 Exponential Gradients - TIRF mCherry images of a HeLa cell transfected with CRY2-mCherry and CIBN-GFP and plated on a round pattern of fibronectin. The area of activation is r...
