A New Strategy for Treating Neuropathic Pain - Conventional methods of pain treatment have often proved ineffective in the treatment of neuropathic pain. Here, in an effort to develop a new therapeuti...
Prefrontal Cortex, Limbic System, and High Performance
Controlling habit formation is a key medical need and a desirable feature of thoughtful behavior when habits could be harmful. This video describes optogenetic manipulations that rendered rats impervi...
Ken Cadwell and colleagues demonstrate that the bacterial sensor Nod2 prevents intestinal inflammation by regulating the intestinal microbiota, particularly the expansion of Bacteroides vulgatus, a co...
Synapse Number Regulates Alcohol Sensitivity - Alcohol-related problems are associated with reduced sensitivity to alcohol. Eddison et al. find that arouser (aru), a predicted adaptor protein, functio...
Meditative Tone with Binaural Beats and Water Sounds
Hair cells are the primary receptor cells for sound and are responsible for our sense of hearing. Hair cells do not normally regenerate after damage and their loss is a major cause of deafness. We sho...
Myc and Multiple Myeloma: Drugging the Undruggable
Myc and Multiple Myeloma: Drugging the Undruggable - Reporting a new small-molecule inhibitor of chromatin-binding bromodomains, James Bradner and Constantine Mitsiades offer a back-door route to bloc...
Nucleosomal Elements that Control the Topography of the Barrier to Transcription
Carlos Bustamante and colleagues explain how different nucleosomal components combine together to create physical impediments to transcription that RNA Pol II must overcome in order to successfully tr...
