Combinatorial Genetic Targeting of GABAergic Neurons
Combinatorial Genetic Targeting of GABAergic Neurons - Article: Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex
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TRPA1 Gain of Function Linked to Human Pain - Mutations in ion channels underlie multiple neurological disorders, including pathological pain states. Although previous work with knock-out mice has sug...
Memory Enhancement by Targeting NR2B Cell Surface Regulation
Many neurological disorders, such as Alzheimer's disease, are characterized by learning and memory deficits, for which cognitive enhancement is considered a valid treatment strategy. Plattner and coll...
Amygdala Predicts Stress Vulnerability - This video summarizes the results of a Duke University study finding that higher amygdala reactivity to threat predicts greater symptoms of anxiety and depress...
Human Mutation - Yuehua Zhang, Liping Wei, and colleagues
Amplicon Resequencing Identified Parental Mosaicism for Approximately 10% of “de novo” SCN1A Mutations in Children with Dravet Syndrome. The majority of children with Dravet syndrome (DS) are caused b...
Deciphering Gene Expression Patterns - Nir Yakoby and Stas Shvartsman discuss the gene expression profiling project that led them to develop this framework for cataloguing and interpreting gene expres...
Environmental Enrichment Rescues Precocious Critical Period
Critical periods are developmental time windows when neural circuits in the brain are shaped by experience. Jianhua Cang and colleagues show that a precocious critical period disrupts the matching of ...
Social jetlag and its consequences. Why are most people in industrialized societies so tired? The reason lies in an increasing discrepancy between our body clocks' internal time and the social demands...
Baron Chanda and colleagues describe the principles for temperature gating in ion channels and how temperature-insensitive channels can be made cold or heat responsive....
Gaining mechanistic insight into age-related obesity can provide clues to developing therapeutic approaches for treating this condition. In this study, Lily Jan and colleagues discover that an increas...
Cancers Chew the Fat - Tumors undergo metabolic changes associated with increased malignancy. Watch and listen as Ben Cravatt and colleagues take you on a personally guided tour of their findings that...
Symbiotic ants defend acacia hosts from elephants - In the savannas of East Africa, tiny symbiotic ants depend on an acacia tree to provide them with housing and food. In return, the ants provide prot...
Retinal Direction Selectivity Is Reversed by Visual Stimulation
A classic neural computation is that of detecting the direction of motion of an object within the visual scene. Direction-selective cells in the retina respond strongly to an image moving in the prefe...
Rethinking Embryonic Germ Layers - Elena Tzouanacou and Val Wilson discuss their interests in mammalian cell lineages and how they came to identify one such lineage that violates a strict assumption o...
miRNA, Notch, and Amygdala-Dependent Fear Learning
In this video, Dias et al. summarize data that shows that a microRNA in the amygdala (miR-34a) regulates Notch signaling after auditory fear conditioning. Their work makes a case for this interaction ...
