Synaptic Pruning in the Developing Nervous System

Synaptic Pruning in the Developing Nervous System - Using light and serial electron microscopy, Jeff Lichtman and colleagues assessed the how axonal branching and synaptic connectivity change with dev...

Prefrontal Cortex, Limbic System, and High Performance

Controlling habit formation is a key medical need and a desirable feature of thoughtful behavior when habits could be harmful. This video describes optogenetic manipulations that rendered rats impervi...

Multiple CaMKII Binding Modes to the Actin Cytoskeleton Revealed by Single Molecule Imaging

Multiple CaMKII Binding Modes to the Actin Cytoskeleton Revealed by Single Molecule Imaging - YouTube...

Control of Glutamate Receptor Function in the Hippocampus

The hippocampus plays a pivotal role for learning and memory. In this video we show how two proteins—CKAMP44 and TARP gamma-8—that bind to AMPA receptors control information flow into the hippocampus....

Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing

Eric Rubin and colleagues describe how tuberculosis bacteria undergo metabolic adaptation to survive attempts by CD4 T cells to starve them of tryptophan. They identify a small-molecule inhibitor of t...

Impacts of Africa's Development Corridors/ Curr. Biol., Nov. 25, 2015 (Vol. 25, Issue 24)

Impacts of Africa's Development Corridors -- Over 53,000 kilometers of development corridors have been proposed or are underway in sub-Saharan Africa. These corridors are intended to rapidly accelerat...

Cell Symposia: Inflammation and Disease

Cell Symposia: Inflammation and Disease ...

Corticogenesis from Pluripotent Stem Cells

In this video, Ira Espuny-Camacho and Pierre Vanderhaeghen describe how human pluripotent stem cells can be turned into cortical pyramidal neurons, mimicking key aspects of human corticogenesis. Most ...

How legs were lost during snake evolution

How Legs Were Lost during Snake Evolution/ Curr. Biol., Oct. 20, 2016 (Vol. 26, Issue 21) - Most snakes are completely limbless, but some snakes diverged from the lineage leading to the advanced snake...

Polymerization Pulls

Polymerization Pulls...

Meg Lowman: An Amazing View of Earth | California Academy of Sciences

Meg Lowman: An Amazing View of Earth | California Academy of Sciences - YouTube...

Sublayer-Specific Coding in Hippocampal Area CA1

Sublayer-Specific Coding in Hippocampal Area CA1 - YouTube...

Environmental Enrichment Rescues Precocious Critical Period

Critical periods are developmental time windows when neural circuits in the brain are shaped by experience. Jianhua Cang and colleagues show that a precocious critical period disrupts the matching of ...

Dynamic Odor Representations

Takaki Komiyama and colleagues used chronic two-photon calcium imaging to explore how wakefulness and experience shape odor representations in the mouse olfactory bulb. Their observations reveal the d...

Connecting the Dots: Linking Sirtuins and AMPK in Metabolism and Aging

Connecting the Dots: Linking Sirtuins and AMPK in Metabolism and Aging - Vittorio Sartorelli and Marcella Fulco discuss their identification of a nutrient-sensing pathway that governs the differentiat...

Human Mutation - Maria Chiara Scaini

Human Mutation - Maria Chiara Scaini - YouTube...

Without these Molecular Machines like this, No RNA

Without these Molecular Machines like this, No RNA ...

Assembly and Functions of a Viral Polymer that Inactivates Multiple Tumor Suppressors

Clodagh O'Shea and colleagues describe how they used a combination of ultrastructural, crystallography, and biochemical studies to show that the adenoviral protein E4-ORF3 forms a multivalent polymer ...

Finding ESCRTs II and III

Finding ESCRTs II and III - Markus Babst and David Katzmann talk about how the ESCRT project started and developed in the Emr lab, and where ESCRTs have gone from there....

Airyscan Fast Imaging for Calcium Signaling, Part 3

Airyscan Fast Imaging for Calcium Signaling, Part 3 ...