The asymmetrical clamp-loader pentamer (green, with pink ATP) spirals around a DNA double helix (yellow) and binds the sliding-clamp trimer (brown) around the DNA in an open lock-washer position....
Children with dyslexia have less brain activity underlying visual motion in area V5/MT compared to controls of the same age; however, this difference does not emerge when the dyslexics are compared to...
How Does CaMKII Sense Specific Calcium Waves? - John Kuriyan and his team reveal a flower-like unfurling mechanism that allows different isoforms of CaMKII to sense particular frequencies of calcium s...
Blebs on the Move - Erez Raz and his colleagues use a tour through their lab to walk you through the approach they took to analyzing the migratory behavior of primordial germ cells in vivo....
The Highs and Lows of EGFR - The binding of epidermal growth factor (EGF) induces dimerization and activation of its receptor, EGFR. Watch as Mark Lemmon and Diego Alvarado take you on a brief, person...
Waking-like brain function in embryos - When in development do brains "wake up" for the first time? Balaban, Desco, and Vaquero (Current Biology, May 3, 2012) addressed this question using n...
Flowers encourage pollinator visitation by producing nectar rewards, but there are also examples of deceptive flowers, such as many orchids, that provide nothing in return for pollination services. Th...
How Legs Were Lost during Snake Evolution/ Curr. Biol., Oct. 20, 2016 (Vol. 26, Issue 21) - Most snakes are completely limbless, but some snakes diverged from the lineage leading to the advanced snake...
Andy Dillin and colleagues show that, in the nematode worm C. elegans, activation of the unfolded protein response (UPR) regulator XBP-1 in neurons produces a signal that stimulates UPR in intestinal ...
Control of Glutamate Receptor Function in the Hippocampus
The hippocampus plays a pivotal role for learning and memory. In this video we show how two proteins—CKAMP44 and TARP gamma-8—that bind to AMPA receptors control information flow into the hippocampus....
Connecting the Dots: Linking Sirtuins and AMPK in Metabolism and Aging
Connecting the Dots: Linking Sirtuins and AMPK in Metabolism and Aging - Vittorio Sartorelli and Marcella Fulco discuss their identification of a nutrient-sensing pathway that governs the differentiat...
